Encainide
- Product Name
- Encainide
- CAS No.
- 37612-13-8
- Chemical Name
- Encainide
- Synonyms
- Encainide;Unii-sy3J0147nb;Encainide [inn:ban];Encainide USP/EP/BP;4-Methoxy-N-(2-(2-(1-Methylpiperidin-2-yl)ethyl)phenyl)benzaMide
- CBNumber
- CB0969673
- Molecular Formula
- C22H28N2O2
- Formula Weight
- 352.475
- MOL File
- 37612-13-8.mol
Encainide Chemical Properties,Usage,Production
Description
Encainide is a membrane-active class I c agent with complex metabolism and clinical pharmacology , . To date, its effectiveness has been proved against ventricular arrhythmias.
Uses
Cardiac depressant (anti-arrhythmic.
Uses
Clinical use of encainide is primarily associated with the presence of serious ventricular tachycardia; however, like flecainide, it is also sufficiently effective for atrial arrhythmia and is used for natural occurrences.
Definition
ChEBI: Encainide is 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a member of piperidines and a member of benzamides.
brand name
Enkaid (Bristol Labs).
World Health Organization (WHO)
The membrane-stabilizing antiarrhythmic agent encainide was introduced into medicine in the mid-1980's. The decision to delete the indications for patients with asymptomatic and less severe symptomatic ventricular arrhythmias was taken on the basis of the results of a trial (CAST study) that showed a two-fold increase in deaths in post-myocardiac patients taking encainide compared with the placebo group. (See also WHO comment for flecainide).
Side effects
Side effects include central nervous system activity.
Synthesis
Encainide, 4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-benzamide (18.1.15), is synthesized by acylating 2-(1-methyl-2-piperidylethyl)aniline with 4- methoxybenzoic acid chloride. The chemical structure of encainide is substantially different than other local anesthetics and antiarrhythmics.